Acquired resistance to the Hedgehog pathway inhibitor vismodegib due to smoothened mutations in treatment of locally advanced basal cell carcinoma

Tjinta Brinkhuizen; Marie G Reinders; Michel van Geel; Annelot J L Hendriksen; Aimée D C Paulussen; Véronique J Winnepenninckx; Kristien B Keymeulen; Patricia M M B Soetekouw; Maurice A M van Steensel; Klara Mosterd

doi:10.1016/j.jaad.2014.08.001

Acquired resistance to the Hedgehog pathway inhibitor vismodegib due to smoothened mutations in treatment of locally advanced basal cell carcinoma

J Am Acad Dermatol. 2014 Nov;71(5):1005-8. doi: 10.1016/j.jaad.2014.08.001. Epub 2014 Sep 4.

Affiliations

¹ Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address: t.brinkhuizen@mumc.nl.
² Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
³ Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
⁴ Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands.
⁵ Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
⁶ Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
⁷ Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
⁸ Division of Medical Oncology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
⁹ Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands; Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands; GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands; Immunos, Institute of Medical Biology, Singapore.

PMID: 25199678
DOI: 10.1016/j.jaad.2014.08.001

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Aged
Anilides / therapeutic use*
Antineoplastic Agents / therapeutic use*
Carcinoma, Basal Cell / drug therapy
Carcinoma, Basal Cell / genetics*
DNA Mutational Analysis
Drug Resistance, Neoplasm / genetics*
Female
Humans
Neoplasm Recurrence, Local / genetics*
Pyridines / therapeutic use*
Receptors, G-Protein-Coupled / genetics*
Skin Neoplasms / drug therapy
Skin Neoplasms / genetics*
Smoothened Receptor

Substances

Anilides
Antineoplastic Agents
HhAntag691
Pyridines
Receptors, G-Protein-Coupled
SMO protein, human
Smoothened Receptor