Abstract
We identified 37 hematopoietic cell transplantation recipients with human herpesvirus 6 (HHV-6) central nervous system dysfunction and tested donor-recipient pairs for chromosomally integrated HHV-6 (ciHHV-6). One patient had ciHHV-6A with possible HHV-6A reactivation and encephalitis. There was no ciHHV-6 enrichment in this group, but larger studies are needed to determine if patients with ciHHV-6 are at increased risk for HHV-6-associated diseases or other complications.
Keywords:
Central nervous system (CNS); Herpesvirus (hhv-6); Integration; Transplant.
Copyright © 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Central Nervous System / metabolism
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Central Nervous System / pathology
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Central Nervous System / virology
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Chromosomes, Human / chemistry
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Chromosomes, Human / virology*
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DNA, Viral / cerebrospinal fluid*
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Encephalitis, Viral / cerebrospinal fluid
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Encephalitis, Viral / genetics
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Encephalitis, Viral / pathology
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Encephalitis, Viral / virology*
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Hematopoietic Stem Cell Transplantation
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Herpesvirus 6, Human / classification
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Herpesvirus 6, Human / genetics*
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Herpesvirus 6, Human / isolation & purification
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Humans
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Molecular Typing
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Phylogeny
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Roseolovirus Infections / cerebrospinal fluid
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Roseolovirus Infections / genetics
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Roseolovirus Infections / pathology
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Roseolovirus Infections / virology*
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Transplantation, Homologous
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Virus Activation
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Virus Integration*