Genetic networks governing heart development

Ashley J Waardenberg; Mirana Ramialison; Romaric Bouveret; Richard P Harvey

doi:10.1101/cshperspect.a013839

Genetic networks governing heart development

Cold Spring Harb Perspect Med. 2014 Oct 3;4(11):a013839. doi: 10.1101/cshperspect.a013839.

Authors

Ashley J Waardenberg¹, Mirana Ramialison², Romaric Bouveret³, Richard P Harvey⁴

Affiliations

¹ Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia.
² Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia St. Vincent's Clinical School, University of New South Wales Medicine, Kensington, New South Wales 2052, Australia Stem Cells Australia, Melbourne Brain Centre, University of Melbourne, Victoria 3010, Australia.
³ Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia St. Vincent's Clinical School, University of New South Wales Medicine, Kensington, New South Wales 2052, Australia.
⁴ Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia St. Vincent's Clinical School, University of New South Wales Medicine, Kensington, New South Wales 2052, Australia School of Biotechnology and Biomolecular Sciences, University of New South Wales Faculty of Science, New South Wales 2052, Australia Stem Cells Australia, Melbourne Brain Centre, University of Melbourne, Victoria 3010, Australia.

Abstract

Animal genomes contain a code for construction of the body plan from a fertilized egg. Understanding how genome information is deciphered to create the complex multilayered regulatory systems that drive organismal development, and which become altered in disease, is one of the greatest challenges in the biological sciences. The development of methods that effectively represent and communicate the complexity inherent in gene regulatory networks remains a major barrier. This review introduces the philosophy of systems biology and discusses recent progress in understanding the development of the heart at a systems biology level.

Publication types

Review

MeSH terms

Animals
Drosophila / embryology
Drosophila / genetics
Drosophila / growth & development
Epigenesis, Genetic / genetics
Gene Expression Profiling
Gene Expression Regulation, Developmental / genetics*
Gene Regulatory Networks / genetics*
Gene Regulatory Networks / physiology
Genome / genetics
Heart / embryology
Heart / growth & development*
Humans
Mice
Musculoskeletal Development
RNA, Untranslated / genetics
RNA, Untranslated / physiology

Substances

RNA, Untranslated