Transgenic mice: 'new wave' immunogenetics

Immunol Today. 1986 May;7(5):138-41. doi: 10.1016/0167-5699(86)90079-4.

Abstract

It is now possible to investigate the function of cloned genes in vivo by injecting the genes into mouse embryos and tracing the pattern of expression of the genes' products. In this review Christophe Benoist and his colleagues discuss the technique of gene transfer, its power and limitations, and its particular application in the study of immune function.