Chemical and medicinal versatility of dithiocarbamates: an overview

Mini Rev Med Chem. 2014;14(12):1021-32. doi: 10.2174/1389557514666141106130146.

Abstract

Dithiocarbamates are considered as the simplest occurring organosulfur compounds exhibiting diverse chemical and medicinal versatility. Dithiocarbamates have been used as pesticide in the 20(th) century but thereafter they have attracted the interest of medicinal chemists due to their metal binding capacity. Recently a variety of chemical and medicinal properties of dithiocarbamates have been explored other than metal binding capacity. This review collectively describes the most significant chemical and medicinal properties of dithiocarbamate derivatives reported over the last decade.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-HIV Agents / chemical synthesis
  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / pharmacology
  • Antifungal Agents / chemical synthesis
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Drug Discovery*
  • HIV / drug effects
  • Humans
  • Mycoses / drug therapy
  • Neoplasms / drug therapy
  • Spermatocidal Agents / chemical synthesis
  • Spermatocidal Agents / chemistry
  • Spermatocidal Agents / pharmacology
  • Thiocarbamates / chemical synthesis
  • Thiocarbamates / chemistry*
  • Thiocarbamates / pharmacology*

Substances

  • Anti-HIV Agents
  • Antifungal Agents
  • Antineoplastic Agents
  • Spermatocidal Agents
  • Thiocarbamates