1 1Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada 2Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand 3Department of Pathology, Karolinska University Hospital, Solna, Stockholm, Sweden 4Aquesta Pathology and University of Queensland, Brisbane, Queensland, Australia 5University Health Network, University of Toronto, Toronto, Ontario, Canada.