Bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution

Ryo Nishihara; Hideyuki Suzuki; Emi Hoshino; Sakura Suganuma; Moritoshi Sato; Tsuyoshi Saitoh; Shigeru Nishiyama; Naoko Iwasawa; Daniel Citterio; Koji Suzuki

doi:10.1039/c4cc06886f

Bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution

Chem Commun (Camb). 2015;51(2):391-4. doi: 10.1039/c4cc06886f. Epub 2014 Nov 18.

Authors

Ryo Nishihara¹, Hideyuki Suzuki, Emi Hoshino, Sakura Suganuma, Moritoshi Sato, Tsuyoshi Saitoh, Shigeru Nishiyama, Naoko Iwasawa, Daniel Citterio, Koji Suzuki

Affiliation

¹ Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan. suzuki@applc.keio.ac.jp.

PMID: 25407088
DOI: 10.1039/c4cc06886f

Abstract

Three novel coelenterazine (CTZ) derivatives with extension at the C-6 position of the imidazopyrazinone structure show significant bioluminescence emission with known renilla luciferase variants, indicating a promising method to develop CTZ derivatives with superior optical properties compared to hitherto reported compounds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Imidazoles / chemistry*
Imidazoles / metabolism
Luciferases, Renilla / metabolism
Luminescent Agents / chemistry*
Luminescent Agents / metabolism
Luminescent Measurements
Pyrazines / chemistry*
Pyrazines / metabolism
Renilla / enzymology
Substrate Specificity

Substances

Imidazoles
Luminescent Agents
Pyrazines
coelenterazine
Luciferases, Renilla