MR of multi-organ involvement in the metabolic syndrome

Abstract

The metabolic syndrome (MetS) is characterized by ectopic lipid accumulation. Magnetic resonance (MR) imaging and spectroscopy can quantify ectopic lipid accumulation. Consequences of MetS can be evaluated with MR on a whole-body level. In the liver, several techniques are used to quantify hepatic steatosis and differentiate stages of nonalcoholic fatty liver disease. Cardiac MR can quantify myocardial steatosis and associated complications. In the brain, magnetization transfer imaging and diffusion tensor imaging can detect microstructural brain damage. Various other organs can be assessed with MR. MR is a powerful tool to unravel whole-body MetS pathophysiology, monitor therapeutic efficacy, and establish prognosis.

Keywords: Diabetic cardiomyopathy; Ectopic lipid accumulation; Fat imaging; Magnetic resonance imaging; Magnetic resonance spectroscopy; Metabolic syndrome; Microstructural brain damage; Nonalcoholic fatty liver disease.