Plant metabolites. Structure and in vitro antiviral activity of quinovic acid glycosides from Uncaria tomentosa and Guettarda platypoda

J Nat Prod. 1989 Jul-Aug;52(4):679-85. doi: 10.1021/np50064a002.

Abstract

A reinvestigation of the bark of Uncaria tomentosa afforded, in addition to the major quinovic acid glycosides 1-3, three further glycosides 4-6. The structures were elucidated by spectral and chemical studies. Furthermore, a series of antiviral tests were performed on all these glycosides and on the related glycosides 7-9, previously isolated from Guettarda platypoda.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / pharmacology*
  • Cell Survival / drug effects
  • Cells, Cultured
  • Chemical Phenomena
  • Chemistry
  • Chromatography, Gas
  • Glycosides / isolation & purification
  • Glycosides / pharmacology
  • HeLa Cells
  • Humans
  • Hydrolysis
  • Magnetic Resonance Spectroscopy
  • Peru
  • Plants, Medicinal / analysis*
  • RNA Viruses / drug effects
  • Rhinovirus / drug effects
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology*
  • Vesicular stomatitis Indiana virus / drug effects

Substances

  • Antiviral Agents
  • Glycosides
  • Triterpenes