Treating type-1 diabetes with an epigenetic drug

Elife. 2014 Dec 30:3:e05720. doi: 10.7554/eLife.05720.

¹ Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Japan.
² Department of Experimental Immunology, World Premier International Immunology Frontier Research Center, the Department of Frontier Research in Tumor Immunology, Graduate School of Medicine, and the Center of Medical Innovation & Translational Research, Osaka University, Suita, Japan nohkura@ifrec.osaka-u.ac.jp.

Abstract

A single drug treats type-1 diabetes in mice by dampening inflammation and enhancing insulin production.

Keywords: NF-KB; autoimmune diabetes; bromodomain inhibitor; immunology; mouse.