What's one phosphate between friends (and foe)?

Cell Host Microbe. 2015 Jan 14;17(1):1-3. doi: 10.1016/j.chom.2014.12.011.

Abstract

Body surfaces are colonized by resident microbes that are remarkably resilient to recurrent immune responses. In the latest issue of Science, Cullen et al. (2015) report that, contrary to prevailing assumptions, bacteria of the colonizing microbiota are resistant to antimicrobial peptides, and identify a common mechanism of resistance.

Publication types

  • Comment

MeSH terms

  • Animals
  • Bacteroides / drug effects*
  • Colitis / microbiology*
  • Drug Resistance, Bacterial / genetics*
  • Gastrointestinal Tract / microbiology*
  • Humans
  • Microbiota / drug effects*
  • Phosphoric Monoester Hydrolases / physiology*
  • Polymyxin B / pharmacology*

Substances

  • Phosphoric Monoester Hydrolases
  • Polymyxin B