A protein restriction-dependent sulfur code for longevity

Hong Seok Shim; Valter D Longo

doi:10.1016/j.cell.2014.12.027

A protein restriction-dependent sulfur code for longevity

Cell. 2015 Jan 15;160(1-2):15-7. doi: 10.1016/j.cell.2014.12.027.

Authors

Hong Seok Shim¹, Valter D Longo²

Affiliations

¹ Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA.
² Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA; Longevity Institute, Davis School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA; IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy. Electronic address: vlongo@usc.edu.

PMID: 25594171
DOI: 10.1016/j.cell.2014.12.027

Abstract

The restriction of proteins has recently emerged as the most important factor for the beneficial effects of calorie restriction. Hine et al. now provide strong evidence for the role of the hydrogen sulfide (H2S) gas in the protective effects of calorie and protein restriction against ischemia/reperfusion injury (IRI) but also implicate H2S in longevity extension in model organisms.

Publication types

Comment

MeSH terms

Animals
Diet*
Female
Hydrogen Sulfide / metabolism*
Male

Substances

Hydrogen Sulfide

Abstract

Publication types

MeSH terms

Substances

Grants and funding