Downregulation of FOXP3 inhibits invasion and immune escape in cholangiocarcinoma

Biochem Biophys Res Commun. 2015 Mar 6;458(2):234-9. doi: 10.1016/j.bbrc.2015.01.067. Epub 2015 Jan 23.

Abstract

FOXP3 is known as a master control of regulatory T cells with recently studies indicating its expression in several tumor cells. In order to study the precise role of FOXP3 in cholangiocarcinoma, FOXP3 was knocked down in cholangiocarcinoma cell lines. Down regulation of FOXP3 inhibits tumor cell invasion by reducing the quantity of MMP-9 and MMP-2. With FOXP3 knocking down, IL-10 and TGF-β1 secreted by cancer cells diminishes and the cell survival of T cells is significant up-regulation. These results suggest that FOXP3 plays an important role in tumor malignant phenotype, especially the invasion and immune escape.

Keywords: Cholangiocarcinoma; FOXP3; Immune escape; Invasion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bile Duct Neoplasms / immunology*
  • Bile Duct Neoplasms / pathology*
  • Bile Ducts, Intrahepatic / immunology*
  • Bile Ducts, Intrahepatic / pathology
  • Cholangiocarcinoma / immunology*
  • Cholangiocarcinoma / pathology*
  • Cytokines / immunology
  • Down-Regulation / immunology
  • Female
  • Forkhead Transcription Factors / immunology*
  • Gene Expression Regulation, Neoplastic / immunology
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Invasiveness / immunology
  • Tumor Escape / immunology*

Substances

  • Cytokines
  • FOXP3 protein, human
  • Forkhead Transcription Factors