Chaos controlled: discovery of a powerful amyloid inhibitor

Roger D Klein; Scott J Hultgren

doi:10.1016/j.molcel.2015.01.031

Chaos controlled: discovery of a powerful amyloid inhibitor

Mol Cell. 2015 Feb 5;57(3):391-3. doi: 10.1016/j.molcel.2015.01.031.

Authors

Roger D Klein¹, Scott J Hultgren²

Affiliations

¹ Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
² Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Center for Women's Infectious Disease Research, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: hultgren@wusm.wustl.edu.

PMID: 25658202
DOI: 10.1016/j.molcel.2015.01.031

Abstract

In this issue of Molecular Cell, Evans et al. (2015) report that the hitherto largely unstudied CsgC protein is responsible for the suppression of premature amyloidogenesis within the cellular periplasm, preventing early aggregation and cellular toxicity.

Publication types

Comment

MeSH terms

Escherichia coli / genetics*
Escherichia coli Proteins / metabolism*
Escherichia coli Proteins / pharmacology*
Humans
Protein Aggregates / drug effects*
alpha-Synuclein / metabolism*

Substances

CsgC protein, E coli
Escherichia coli Proteins
Protein Aggregates
alpha-Synuclein
csgA protein, E coli