Do mutational dynamics in stem cells explain the origin of common cancers?

Gerry P Crossan; Juan I Garaycoechea; Ketan J Patel

doi:10.1016/j.stem.2015.01.009

Do mutational dynamics in stem cells explain the origin of common cancers?

Cell Stem Cell. 2015 Feb 5;16(2):111-2. doi: 10.1016/j.stem.2015.01.009.

Authors

Gerry P Crossan¹, Juan I Garaycoechea², Ketan J Patel³

Affiliations

¹ MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address: gcrossan@mrc-lmb.cam.ac.uk.
² MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
³ MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address: kjp@mrc-lmb.cam.ac.uk.

PMID: 25658366
DOI: 10.1016/j.stem.2015.01.009

Abstract

For more than 60 years, we have known that the incidence of certain common human cancers increases with age. Recently in Science, Tomasetti and Vogelstein (2015) refined this model by providing a potential explanation, arguing that early random mutational events within individual stem cells of regenerating organs may underlie this correlation.

Publication types

Comment

MeSH terms

Cell Division / genetics*
Humans
Neoplasms / epidemiology*
Neoplasms / genetics*
Stem Cells / physiology*

Abstract

Publication types

MeSH terms

Grants and funding