Mycobacterium avium complex (MAC) infection is a common complication of the later stages of AIDS. Extrapulmonary infection with MAC in HIV-negative patients is considered uncommon. We report a case of a young female who presented with fever of unknown origin on multiple occasions and failed to be diagnosed with MAC by acid-fast stain initially. Subsequently, the patient presented with pancytopenia due to bone marrow biopsy-proven infection with MAC. The patient was not on any immunosuppressant regimen.