Myc mouse and anti-ageing therapy

Nazif Alic; Linda Partridge

doi:10.1016/j.tem.2015.02.005

Myc mouse and anti-ageing therapy

Trends Endocrinol Metab. 2015 Apr;26(4):163-4. doi: 10.1016/j.tem.2015.02.005. Epub 2015 Feb 26.

Authors

Nazif Alic¹, Linda Partridge²

Affiliations

¹ Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK.
² Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany. Electronic address: l.partridge@ucl.ac.uk.

PMID: 25727046
DOI: 10.1016/j.tem.2015.02.005

Abstract

Reduction in the expression and activity of a well-known proto-oncogene, Myc, has a beneficial effect on mouse health and survival to old age, in part independently of cancer impact, a recent study reveals. Is this new anti-ageing intervention pointing a way towards new treatments for age-related diseases?

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging*
Animals
Chronic Disease / prevention & control*
Down-Regulation*
Health Status*
Humans
Mice
Models, Biological*
Proto-Oncogene Mas
Proto-Oncogene Proteins c-myc / genetics
Proto-Oncogene Proteins c-myc / metabolism*

Substances

MAS1 protein, human
MYC protein, human
Myc protein, mouse
Proto-Oncogene Mas
Proto-Oncogene Proteins c-myc

Grants and funding

098565/Wellcome Trust/United Kingdom