Intracerebroventricular (ICV) clonidine produces an antianalgesic effect through spinal dynorphin A(1-17) mediation

NIDA Res Monogr. 1989:95:306-7.
No abstract available

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Clonidine / pharmacology*
  • Dose-Response Relationship, Drug
  • Dynorphins / physiology*
  • Injections, Intraventricular
  • Male
  • Mice
  • Mice, Inbred ICR
  • Morphine / antagonists & inhibitors
  • Morphine / pharmacology
  • Nociceptors / drug effects*
  • Spinal Cord / drug effects*

Substances

  • Dynorphins
  • Morphine
  • Clonidine