n-Decyl-NHpppA2'p5'A2'p5'A A phosphatase-resistant, active pppA2'p5'A2'p5'A analog

Biochem Biophys Res Commun. 1985 Apr 30;128(2):695-8. doi: 10.1016/0006-291x(85)90102-0.

Abstract

n-Decyl-NHpppA2'p5'A2'p5'A, a gamma-substituted, phosphatase-resistant pppA2'p5'A2'p5'A analog, gives similar rRNA degradation pattern in interferon-treated HeLa cell extracts--even at a concentration of 10(-9)M--as the natural compound does.

MeSH terms

  • Adenine Nucleotides / pharmacology*
  • Alkaline Phosphatase / metabolism*
  • Endoribonucleases / metabolism*
  • Enzyme Activation
  • HeLa Cells / drug effects
  • Humans
  • Interferons / pharmacology
  • Oligonucleotides / pharmacology*
  • Oligoribonucleotides / pharmacology*
  • RNA, Ribosomal / metabolism

Substances

  • Adenine Nucleotides
  • Oligonucleotides
  • Oligoribonucleotides
  • RNA, Ribosomal
  • Interferons
  • P(1)-adenylyl-5'-2'-adenylyl-5'-2'-adenosyl-P(3)-n-decylaminotriphosphate
  • Endoribonucleases
  • 2-5A-dependent ribonuclease
  • Alkaline Phosphatase