Abstract
n-Decyl-NHpppA2'p5'A2'p5'A, a gamma-substituted, phosphatase-resistant pppA2'p5'A2'p5'A analog, gives similar rRNA degradation pattern in interferon-treated HeLa cell extracts--even at a concentration of 10(-9)M--as the natural compound does.
MeSH terms
-
Adenine Nucleotides / pharmacology*
-
Alkaline Phosphatase / metabolism*
-
Endoribonucleases / metabolism*
-
Enzyme Activation
-
HeLa Cells / drug effects
-
Humans
-
Interferons / pharmacology
-
Oligonucleotides / pharmacology*
-
Oligoribonucleotides / pharmacology*
-
RNA, Ribosomal / metabolism
Substances
-
Adenine Nucleotides
-
Oligonucleotides
-
Oligoribonucleotides
-
RNA, Ribosomal
-
Interferons
-
P(1)-adenylyl-5'-2'-adenylyl-5'-2'-adenosyl-P(3)-n-decylaminotriphosphate
-
Endoribonucleases
-
2-5A-dependent ribonuclease
-
Alkaline Phosphatase