Experimental modulation and computational model of nano-hydrophobicity

Biomaterials. 2015 Jun:52:312-7. doi: 10.1016/j.biomaterials.2015.02.043. Epub 2015 Feb 28.

Abstract

We demonstrate that nano-hydrophobicity, which governs the biological aggressiveness of nanoparticles, is determined by the outermost regions of surface ligands. We have also successfully modulated nano-hydrophobicity using systematic surface ligand modifications and built the first computational model of nano-hydrophobicity.

Keywords: Cytotoxicity; Gold; Hydrophilicity/hydrophobicity; Macrophages; Nanoparticle; Transmission electron microscopy (TEM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Survival
  • Chromatography, High Pressure Liquid
  • Computer Simulation
  • Gold / chemistry
  • Humans
  • Hydrophobic and Hydrophilic Interactions*
  • Ligands
  • Light
  • Macrophages / drug effects
  • Magnetic Resonance Spectroscopy
  • Metal Nanoparticles / chemistry*
  • Microscopy, Electron, Transmission
  • Nanotechnology / methods*
  • Scattering, Radiation
  • Surface Properties

Substances

  • Ligands
  • Gold