Cognitive and neuropsychiatric disease manifestations in MS

A Feinstein; J DeLuca; B T Baune; M Filippi; H Lassman

doi:10.1016/j.msard.2012.08.001

Cognitive and neuropsychiatric disease manifestations in MS

Mult Scler Relat Disord. 2013 Jan;2(1):4-12. doi: 10.1016/j.msard.2012.08.001. Epub 2012 Sep 25.

Authors

A Feinstein¹, J DeLuca², B T Baune³, M Filippi⁴, H Lassman⁵

Affiliations

¹ University of Toronto, Department of Psychiatry and Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M5R 3B6. Electronic address: antfeinstein@aol.com.
² Kessler Foundation Research Center, West Orange, New Jersey, USA.
³ Department of Psychiatry, University of Adelaide, Adelaide, Australia.
⁴ Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.
⁵ Center for Brain Research, Medical University of Vienna, Vienna, Austria.

PMID: 25877449
DOI: 10.1016/j.msard.2012.08.001

Abstract

Multiple sclerosis is associated with a wide array of behavioral problems. This brief overview begins with a summary of the pathophysiology and treatment of MS. Thereafter, sections are devoted to psychiatric syndromes and cognitive decline linked to MS. The immune basis and brain imaging data associated with these changes are subsequently reviewed. The frequency and severity of these changes in mentation highlight the point that MS patients should, as part of their routine care, have access to psychiatrists, neuropsychologists and allied mental health specialists.

Keywords: Cognition; Depression; MRI; Multiple sclerosis; Neuropathology; Neuropsychiatry.

Publication types

Review