Co₉ Se₈ nanoplates as a new theranostic platform for photoacoustic/magnetic resonance dual-modal-imaging-guided chemo-photothermal combination therapy

Xiao-Rong Song; Xiaoyong Wang; Shu-Xian Yu; Jianbo Cao; Shi-Hua Li; Juan Li; Gang Liu; Huang-Hao Yang; Xiaoyuan Chen

doi:10.1002/adma.201405634

Co₉ Se₈ nanoplates as a new theranostic platform for photoacoustic/magnetic resonance dual-modal-imaging-guided chemo-photothermal combination therapy

Adv Mater. 2015 Jun 3;27(21):3285-91. doi: 10.1002/adma.201405634. Epub 2015 Apr 17.

Authors

Xiao-Rong Song¹, Xiaoyong Wang², Shu-Xian Yu¹, Jianbo Cao², Shi-Hua Li¹, Juan Li¹, Gang Liu², Huang-Hao Yang¹, Xiaoyuan Chen³

Affiliations

¹ The Key Lab of Analysis and Detection Technology for Food Safety of the MOE State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry Fuzhou University, Fuzhou, 350108, PR China.
² State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University, Xiamen, 361005, PR China.
³ Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), MD, 20892, USA.

Abstract

A new theranostic platform is developed based on biocompatible poly(acrylic acid) (PAA)-Co9 Se8 nanoplates. These PAA-Co9 Se8 nanoplates are successfully utilized for photoacoustic imaging (PAI)/magnetic resonance imaging (MRI) dual-modal imaging. Moreover, the PAA-Co9 Se8 -DOX shows pH-responsive chemotherapy and enables the combination of photothermal therapy and chemotherapy to receive superior antitumor efficacy. This work promises further exploration of 2D nanoplatforms for theranostic applications.

Keywords: chemotherapy; magnetic resonance imaging; nanoplates; photoacoustic imaging; photothermal therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrylic Resins / chemical synthesis
Acrylic Resins / chemistry
Antineoplastic Agents / administration & dosage
Biocompatible Materials / chemical synthesis
Biocompatible Materials / chemistry
Cell Survival / drug effects
Cell Survival / radiation effects
Cobalt* / chemistry
Combined Modality Therapy / instrumentation
Combined Modality Therapy / methods
Contrast Media / chemical synthesis
Contrast Media / chemistry
Hep G2 Cells
Humans
Hydrogen-Ion Concentration
Magnetic Resonance Imaging / instrumentation*
Magnetic Resonance Imaging / methods
Materials Testing
Multimodal Imaging / instrumentation
Multimodal Imaging / methods
Nanostructures* / chemistry
Neoplasm Transplantation
Photoacoustic Techniques / instrumentation*
Photoacoustic Techniques / methods
Phototherapy / instrumentation
Phototherapy / methods
Selenium Compounds* / chemical synthesis
Selenium Compounds* / chemistry
Theranostic Nanomedicine / instrumentation*
Theranostic Nanomedicine / methods

Substances

Acrylic Resins
Antineoplastic Agents
Biocompatible Materials
Contrast Media
Selenium Compounds
Cobalt
carbopol 940

Abstract

Publication types

MeSH terms

Substances

Grants and funding