Tet2: breaking down barriers to T cell cytokine expression

Chao Zhong; Jinfang Zhu

doi:10.1016/j.immuni.2015.04.003

Tet2: breaking down barriers to T cell cytokine expression

Immunity. 2015 Apr 21;42(4):593-5. doi: 10.1016/j.immuni.2015.04.003.

Authors

Chao Zhong¹, Jinfang Zhu²

Affiliations

¹ Molecular and Cellular Immunoregulation Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
² Molecular and Cellular Immunoregulation Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: jfzhu@niaid.nih.gov.

PMID: 25902474
DOI: 10.1016/j.immuni.2015.04.003

Abstract

It has been unclear whether alteration in DNA methylation at cytokine genes during T helper (Th) cell differentiation is a cause or consequence of gene expression. In this issue of Immunity, Ichiyama et al. (2015) show that oxidation of 5-methylcytosine by the methylcytosine dioxygenase Tet2 regulates cytokine production in Th cells.

Publication types

Research Support, N.I.H., Intramural
Comment

MeSH terms

Animals
Cytokines / biosynthesis*
DNA-Binding Proteins / immunology*
Epigenesis, Genetic / immunology*
Humans
Proto-Oncogene Proteins / immunology*
Th1 Cells / immunology*
Th17 Cells / immunology*

Substances

Cytokines
DNA-Binding Proteins
Proto-Oncogene Proteins

Grants and funding

ZIA AI001169-03/Intramural NIH HHS/United States