[Molecular biology of castration-resistant prostate cancer]

Abstract

Castration-resistant prostate cancer was subjected to a paradigm switch from hormone resistance to androgen deprivation therapy resistance during the last decade. Indeed, new therapeutics targeting the androgen receptor showed clinical efficacy in patients with progressive disease under castration. Thus, it is a proof that the AR remains a dominant driver of oncogenesis in earlier-called hormone resistant prostate cancer. This review summarizes the molecular mechanisms involved in castration-resistant prostate cancer.

Keywords: Androgen receptor; Biologie moléculaire; Cancer de la prostate; Castration resistance; Molecular biology; Prostate cancer; Récepteur aux androgènes; Résistance à la castration.