Abstract
The importance of neutralizing antibodies (NAbs) in protection against hepatitis C virus (HCV) remains controversial. We infused a chimpanzee with H06 immunoglobulin from a genotype 1a HCV-infected patient and challenged with genotype strains efficiently neutralized by H06 in vitro. Genotype 1a NAbs afforded no protection against genotype 4a or 5a. Protection against homologous 1a lasted 18 weeks, but infection emerged when NAb titers waned. However, 6a infection was prevented. The differential in vivo neutralization patterns have implications for HCV vaccine development.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Neutralizing / immunology
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Antibodies, Neutralizing / therapeutic use*
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Ape Diseases / immunology
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Ape Diseases / prevention & control
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Cross Reactions / immunology
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Genotype
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Hepacivirus / immunology*
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Hepatitis C Antibodies / immunology
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Hepatitis C Antibodies / therapeutic use*
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Humans
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Immunization, Passive
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Immunoglobulins / immunology
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Immunoglobulins / therapeutic use*
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Pan troglodytes / virology
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Viral Hepatitis Vaccines / immunology
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Viral Hepatitis Vaccines / therapeutic use*
Substances
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Antibodies, Neutralizing
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Hepatitis C Antibodies
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Immunoglobulins
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Viral Hepatitis Vaccines