Abstract
Novel, quinolone-fluoroquinolone conjugates 10a-f, 11a-f, 13a-f and 14a-f with amino acid linkers were synthesized in good yields utilizing benzotriazole chemistry. Antibacterial bioassay showed the synthesized bis-conjugates exhibit anti-bacterial properties comparable with the parent drugs.
Keywords:
Amino acids; Anti-bacterial; Conjugates; Fluoroquinolone; QSAR; Quinolone.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Dose-Response Relationship, Drug
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Gram-Negative Bacteria / drug effects*
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Gram-Positive Bacteria / drug effects*
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Microbial Sensitivity Tests
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Molecular Structure
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Quantitative Structure-Activity Relationship*
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Quinolones / chemical synthesis
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Quinolones / chemistry
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Quinolones / pharmacology*
Substances
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Anti-Bacterial Agents
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Quinolones