Cesarean Section Delivery Is Not a Risk Factor for Development of Inflammatory Bowel Disease: A Population-based Analysis

Charles N Bernstein; Ankona Banerjee; Laura E Targownik; Harminder Singh; Jean Eric Ghia; Charles Burchill; Dan Chateau; Leslie L Roos

doi:10.1016/j.cgh.2015.08.005

Cesarean Section Delivery Is Not a Risk Factor for Development of Inflammatory Bowel Disease: A Population-based Analysis

Clin Gastroenterol Hepatol. 2016 Jan;14(1):50-7. doi: 10.1016/j.cgh.2015.08.005. Epub 2015 Aug 8.

Authors

Charles N Bernstein¹, Ankona Banerjee², Laura E Targownik³, Harminder Singh⁴, Jean Eric Ghia³, Charles Burchill⁵, Dan Chateau⁵, Leslie L Roos²

Affiliations

¹ University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Canada; Department of Internal Medicine, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. Electronic address: charles.bernstein@med.umanitoba.ca.
² Manitoba Centre for Health Policy, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Department of Community Health Sciences, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
³ University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Canada; Department of Internal Medicine, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
⁴ University of Manitoba Inflammatory Bowel Disease Clinical and Research Centre, Winnipeg, Canada; Department of Internal Medicine, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Department of Community Health Sciences, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
⁵ Manitoba Centre for Health Policy, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

PMID: 26264640
DOI: 10.1016/j.cgh.2015.08.005

Abstract

Background & aims: Mode of birth affects development of the intestinal microbiota, and microbial dysbiosis has been associated with inflammatory bowel disease (IBD). We performed a population-based analysis to determine whether mode of delivery (cesarean section vs. vaginal delivery) affects risk of IBD.

Methods: We collected data from the University of Manitoba IBD Epidemiology Database, which contains records on all Manitobans diagnosed with IBD from 1984 through 2010. Starting in 1970, 6-digit family health registration numbers were used in Manitoba to link mothers with their offspring. Maternal health records, including dates and modes of delivery and siblings of individuals with IBD, were identified.

Results: We obtained data on 1671 individuals with IBD and 10,488 controls (individuals without IBD, matched by age, sex, and area of residence at IBD diagnosis) linked to mothers' obstetrical records. Higher proportions of urban than rural residents were delivered by cesarean section for IBD cases (12.8% vs. 9.7%, P = .05) and controls (13.3% vs. 9.4%, P < .0001). A higher percentage of men with Crohn's disease than women with Crohn's disease were born via cesarean section (13.5% vs. 8.4%, P = .01). Overall, there was no difference in the percentage of IBD cases born by cesarean section (11.6%) vs. controls (11.7%, P = .93). In multivariate analysis, birth by cesarean section was not associated with an increased risk of subsequent IBD, controlling for age, sex, urban residence, and income (odds ratio, 1.04; 95% confidence interval, 0.89-1.23). Persons with IBD were no more likely to have been born by cesarean section than their siblings without IBD (1740 siblings from 1615 families) (11.6% vs. 11.3%; odds ratio, 1.14; 95% confidence interval, 0.72-1.80; P = .79).

Conclusions: People with IBD were not more likely to have been born via cesarean section than controls or siblings without IBD. These findings indicate that events of the immediate postpartum period that shape the developing intestinal microbiome do not affect risk for IBD.

Keywords: Breastfeeding; Method of Birth; Population Study; UMIBDED.

MeSH terms

Adolescent
Adult
Cesarean Section / adverse effects*
Child
Child, Preschool
Female
Hospitals, University
Humans
Infant
Inflammatory Bowel Diseases / epidemiology*
Inflammatory Bowel Diseases / etiology*
Male
Manitoba / epidemiology
Risk Factors
Young Adult