GABA receptors in a state of fear

Andrew Holmes; Alon Chen

doi:10.1038/nn.4098

GABA receptors in a state of fear

Nat Neurosci. 2015 Sep;18(9):1194-6. doi: 10.1038/nn.4098.

Authors

Andrew Holmes¹, Alon Chen²

Affiliations

¹ Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA, and.
² Ruhman Family Laboratory for Research on the Neurobiology of Stress, Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel, and the Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.

PMID: 26308977
PMCID: PMC4970428
DOI: 10.1038/nn.4098

Abstract

Our internal states can color our memories just as powerfully as the external environment. A study finds that hippocampal GABA_A receptors and associated microRNAs are important for generating state-dependent contextual fear memories.

Publication types

Comment

MeSH terms

Animals
Conditioning, Psychological / physiology*
Fear / physiology*
Hippocampus / metabolism*
Male
MicroRNAs / physiology*
Receptors, GABA-A / metabolism*

Substances

MicroRNAs
Receptors, GABA-A

Grants and funding

Z01 AA000411-05/Intramural NIH HHS/United States