Abstract
Acetaminophen hepatotoxicity is characterized by extensive necrotic cell death and a sterile inflammatory response. A recent report suggested that a therapeutic intervention with chlorogenic acid, a dietary polyphenolic compound, protects against acetaminophen-induced liver injury by inhibiting the inflammatory injury. The purpose of this letter is to discuss a number of reasons why the protective mechanism of chlorogenic acid against acetaminophen hepatotoxicity does not involve an anti-inflammatory effect and provides an alternative explanation for the observed protection.
Keywords:
Acetaminophen hepatotoxicity; Natural products; Neutrophils; Sterile inflammation.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Letter
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Research Support, N.I.H., Extramural
MeSH terms
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Acetaminophen / immunology
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Acetaminophen / toxicity*
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Alanine Transaminase
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Analgesics, Non-Narcotic / immunology
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Analgesics, Non-Narcotic / toxicity*
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Animals
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Anti-Inflammatory Agents / therapeutic use
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Apoptosis
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Chemical and Drug Induced Liver Injury / complications
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Chemical and Drug Induced Liver Injury / drug therapy*
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Chemical and Drug Induced Liver Injury / immunology*
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Chlorogenic Acid / therapeutic use*
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Humans
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Inflammation / complications
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Inflammation / drug therapy
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Inflammation / immunology
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Liver / drug effects*
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Liver / immunology
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Protective Agents / therapeutic use*
Substances
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Analgesics, Non-Narcotic
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Anti-Inflammatory Agents
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Protective Agents
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Chlorogenic Acid
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Acetaminophen
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Alanine Transaminase