Acetaminophen hepatotoxicity and sterile inflammation: The mechanism of protection of Chlorogenic acid

Chem Biol Interact. 2016 Jan 5:243:148-9. doi: 10.1016/j.cbi.2015.08.025. Epub 2015 Sep 10.

Abstract

Acetaminophen hepatotoxicity is characterized by extensive necrotic cell death and a sterile inflammatory response. A recent report suggested that a therapeutic intervention with chlorogenic acid, a dietary polyphenolic compound, protects against acetaminophen-induced liver injury by inhibiting the inflammatory injury. The purpose of this letter is to discuss a number of reasons why the protective mechanism of chlorogenic acid against acetaminophen hepatotoxicity does not involve an anti-inflammatory effect and provides an alternative explanation for the observed protection.

Keywords: Acetaminophen hepatotoxicity; Natural products; Neutrophils; Sterile inflammation.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Acetaminophen / immunology
  • Acetaminophen / toxicity*
  • Alanine Transaminase
  • Analgesics, Non-Narcotic / immunology
  • Analgesics, Non-Narcotic / toxicity*
  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Apoptosis
  • Chemical and Drug Induced Liver Injury / complications
  • Chemical and Drug Induced Liver Injury / drug therapy*
  • Chemical and Drug Induced Liver Injury / immunology*
  • Chlorogenic Acid / therapeutic use*
  • Humans
  • Inflammation / complications
  • Inflammation / drug therapy
  • Inflammation / immunology
  • Liver / drug effects*
  • Liver / immunology
  • Protective Agents / therapeutic use*

Substances

  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Protective Agents
  • Chlorogenic Acid
  • Acetaminophen
  • Alanine Transaminase