How to outsmart NK cell tolerance

Grzegorz Terszowski; Christian Klein; Laurent Schmied; Martin Stern

doi:10.1080/2162402X.2015.1016708

How to outsmart NK cell tolerance

Oncoimmunology. 2015 Apr 2;4(9):e1016708. doi: 10.1080/2162402X.2015.1016708. eCollection 2015 Sep.

Authors

Grzegorz Terszowski¹, Christian Klein², Laurent Schmied¹, Martin Stern³

Affiliations

¹ Department of Biomedicine; University Hospital Basel ; Basel, Switzerland.
² Roche Pharma Research and Early Development; Roche Innovation Center Zurich ; Schlieren, Switzerland.
³ Department of Biomedicine; University Hospital Basel ; Basel, Switzerland ; Roche Pharma Research and Early Development; Roche Innovation Center Zurich ; Schlieren, Switzerland.

Abstract

Immune tolerance induced by regulatory mechanisms is an integral and fundamental part of immunity. In therapeutic settings, however, tolerance may significantly limit efficacy. Here, we summarize possible strategies to enhance therapeutic antibody dependent cellular cytotoxicity by overcoming NK cell tolerance.

Keywords: ADCC; CD20; HLA; KIR; NK cell tolerance; lirilumab; obinutuzumab; rituximab.

Publication types

Research Support, Non-U.S. Gov't