Impact of Gut Microbiota on Obesity, Diabetes, and Cardiovascular Disease Risk

Luca Miele; Valentina Giorgio; Maria Adele Alberelli; Erica De Candia; Antonio Gasbarrini; Antonio Grieco

doi:10.1007/s11886-015-0671-z

Impact of Gut Microbiota on Obesity, Diabetes, and Cardiovascular Disease Risk

Curr Cardiol Rep. 2015 Dec;17(12):120. doi: 10.1007/s11886-015-0671-z.

Authors

Luca Miele^{1

2}, Valentina Giorgio³, Maria Adele Alberelli⁴, Erica De Candia⁵, Antonio Gasbarrini⁶, Antonio Grieco⁷

Affiliations

¹ Institute of Internal Medicine, Policlinico Gemelli Hospital, Catholic University of Sacred Heart of Rome, Rome, Italy. luca.miele@rm.unicatt.it.
² Clinical Division of Internal Medicine, Gastroenterology and Liver Unit, Complesso Integrato Columbus Hospital, Catholic University of Sacred Heart of Rome, Rome, Italy. luca.miele@rm.unicatt.it.
³ Pediatric Department, Policlinico Gemelli Hospital, Catholic University of Sacred Heart of Rome, Rome, Italy. valentina.giorgio@rm.unicatt.it.
⁴ Institute of Internal Medicine, Policlinico Gemelli Hospital, Catholic University of Sacred Heart of Rome, Rome, Italy. mariadele.alberelli@gmail.com.
⁵ Institute of Internal Medicine, Policlinico Gemelli Hospital, Catholic University of Sacred Heart of Rome, Rome, Italy. edecandia@rm.unicatt.it.
⁶ Institute of Internal Medicine, Policlinico Gemelli Hospital, Catholic University of Sacred Heart of Rome, Rome, Italy. agasbarrini@rm.unicatt.it.
⁷ Institute of Internal Medicine, Policlinico Gemelli Hospital, Catholic University of Sacred Heart of Rome, Rome, Italy. agrieco@rm.unicatt.it.

PMID: 26497040
DOI: 10.1007/s11886-015-0671-z

Abstract

Gut microbiota has been recently established to have a contributory role in the development of cardiometabolic disorders, such as atherosclerosis, obesity, and type 2 diabetes. Growing interest has focused on the modulation of gut microbiota as a therapeutic strategy in cardiovascular diseases and metabolic disorders. In this paper, we have reviewed the impact of gut microbiota on metabolic disorders and cardiovascular disease risk, focusing on the newest findings in this field.

Keywords: Cardiovascular disease; Gut microbiota; Obesity; Platelets; Type 2 diabetes.

Publication types

Review

MeSH terms

Bacterial Physiological Phenomena
Cardiovascular Diseases / microbiology*
Cardiovascular Diseases / physiopathology
Cardiovascular Diseases / prevention & control
Diabetes Mellitus, Type 2 / microbiology*
Diabetes Mellitus, Type 2 / physiopathology
Diabetes Mellitus, Type 2 / prevention & control
Gastrointestinal Microbiome
Gastrointestinal Tract / microbiology*
Humans
Inflammation / microbiology*
Inflammation / physiopathology
Insulin Resistance
Obesity / microbiology*
Obesity / physiopathology
Obesity / prevention & control
Probiotics / therapeutic use