Bioinformatics prioritization of SNPs perturbing microRNA regulation of hematological malignancy-implicated genes

Genomics. 2015 Dec;106(6):360-6. doi: 10.1016/j.ygeno.2015.10.004. Epub 2015 Oct 29.

Abstract

The contribution of microRNAs (miRNAs) to cancer has been extensively investigated and it became obvious that a strict regulation of miRNA-mRNA regulatory network is crucial for safeguarding cell health. Apart from the direct impact of miRNA dysregulation in cancer pathogenesis, genetic variations in miRNAs are likely to disrupt miRNA-target interaction. Indeed, many evidences suggested that SNPs within miRNA regulome are associated with the development of different hematological malignancies. However, a full catalog of SNPs within miRNAs target sites of genes relevant to hematopoiesis and hematological malignancies is still lacking. Accordingly, we aimed to systematically identify and characterize such SNPs and provide a prioritized list of most potentially disrupting SNPs. Although in the present study we did not address the functional significance of these potential disturbing variants, we believe that our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.

Keywords: Hematological malignancy; Leukemia; MicroRNA; Single nucleotide polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computational Biology / methods*
  • Gene Expression Regulation, Neoplastic*
  • Genetic Predisposition to Disease / genetics
  • Genome-Wide Association Study / methods
  • Hematologic Neoplasms / genetics*
  • Humans
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism
  • Polymorphism, Single Nucleotide*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Reproducibility of Results

Substances

  • MicroRNAs
  • RNA, Messenger