Abstract
The development of practical and efficient surgical sealants has the propensity to improve operational outcomes. A biodegradable polymer blend is fabricated as a nonwoven fiber mat in situ. After direct deposition onto the tissue of interest, the material transitions from a fiber mat to a film. This transition promotes polymer-substrate interfacial interactions leading to improved adhesion and surgical sealant performance.
Keywords:
biodegradable polymers; solution blow spinning; surgical sealants; temperature responsive.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adhesives / chemistry
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Adhesives / metabolism
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Adhesives / pharmacology*
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Animals
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Biocompatible Materials / chemistry
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Biocompatible Materials / metabolism
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Biocompatible Materials / pharmacology*
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Body Temperature*
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Lactic Acid / chemistry
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Mice
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Polyethylene Glycols / chemistry
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Polyglycolic Acid / chemistry
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polymers / chemistry
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Polymers / metabolism
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Polymers / pharmacology*
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Surgical Equipment*
Substances
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Adhesives
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Biocompatible Materials
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Polymers
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polyglycolic Acid
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Lactic Acid
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Polyethylene Glycols