Biodegradable-Polymer-Blend-Based Surgical Sealant with Body-Temperature-Mediated Adhesion

Adv Mater. 2015 Dec 22;27(48):8056-61. doi: 10.1002/adma.201503691. Epub 2015 Nov 10.

Abstract

The development of practical and efficient surgical sealants has the propensity to improve operational outcomes. A biodegradable polymer blend is fabricated as a nonwoven fiber mat in situ. After direct deposition onto the tissue of interest, the material transitions from a fiber mat to a film. This transition promotes polymer-substrate interfacial interactions leading to improved adhesion and surgical sealant performance.

Keywords: biodegradable polymers; solution blow spinning; surgical sealants; temperature responsive.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesives / chemistry
  • Adhesives / metabolism
  • Adhesives / pharmacology*
  • Animals
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / metabolism
  • Biocompatible Materials / pharmacology*
  • Body Temperature*
  • Lactic Acid / chemistry
  • Mice
  • Polyethylene Glycols / chemistry
  • Polyglycolic Acid / chemistry
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polymers / chemistry
  • Polymers / metabolism
  • Polymers / pharmacology*
  • Surgical Equipment*

Substances

  • Adhesives
  • Biocompatible Materials
  • Polymers
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Lactic Acid
  • Polyethylene Glycols