Abstract
Candida biofilm-associated infections of central venous catheters are a challenging therapeutic problem. Recent in vitro and in vivo studies of the structure, formation, pathogenesis, and treatment establish a rationale for new approaches to management of these tenacious infections.
Keywords:
anidulafungin; biofilm; caspofungin; echinocandin; micafungin.
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anidulafungin
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Animals
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Antifungal Agents / pharmacology
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Antifungal Agents / therapeutic use*
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Biofilms / drug effects*
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Candida / drug effects*
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Candida / physiology
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Candidiasis / drug therapy
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Candidiasis / microbiology
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Caspofungin
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Catheter-Related Infections / drug therapy*
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Catheter-Related Infections / microbiology
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Disease Models, Animal
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Drug Resistance, Fungal
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Echinocandins / pharmacology*
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Echinocandins / therapeutic use*
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Humans
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Lipopeptides / pharmacology
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Lipopeptides / therapeutic use
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Micafungin
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Microbial Sensitivity Tests
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Vascular Access Devices*
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Anidulafungin
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Caspofungin
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Micafungin