Long noncoding RNAs in hematopoietic malignancies

Norma I Rodríguez-Malavé; Dinesh S Rao

doi:10.1093/bfgp/elv047

Long noncoding RNAs in hematopoietic malignancies

Brief Funct Genomics. 2016 May;15(3):227-38. doi: 10.1093/bfgp/elv047. Epub 2015 Nov 26.

Authors

Norma I Rodríguez-Malavé¹, Dinesh S Rao²

Affiliations

¹ Cellular and Molecular Pathology Program, Department of Pathology and Laboratory Medicine, University of California Los Angeles, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, University of California Los Angeles Cellular and Molecular Pathology Program, Department of Pathology and Laboratory Medicine, University of California Los Angeles, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, University of California Los Angeles.
² Cellular and Molecular Pathology Program, Department of Pathology and Laboratory Medicine, University of California Los Angeles, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, University of California Los Angeles Cellular and Molecular Pathology Program, Department of Pathology and Laboratory Medicine, University of California Los Angeles, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, University of California Los Angeles Cellular and Molecular Pathology Program, Department of Pathology and Laboratory Medicine, University of California Los Angeles, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, University of California Los Angeles drao@mendet.ucla.edu.

PMID: 26612601
DOI: 10.1093/bfgp/elv047

Abstract

Recent years have witnessed the discovery of several classes of noncoding RNAs (ncRNAs), which are indispensable for the regulation of cellular processes. Many of these RNAs are regulatory in nature with functions in gene expression regulation such as piwi-interacting RNAs, small interfering RNAs and micro RNAs. Long noncoding RNAs (lncRNAs) comprise the most recently characterized class. LncRNAs are involved in transcriptional regulation, chromatin remodeling, imprinting, splicing, and translation, among other critical functions in the cell. Recent studies have elucidated the importance of lncRNAs in hematopoietic development. Dysregulation of lncRNA expression is a feature of various diseases and cancers, and is also seen in hematopoietic malignancies. This article focuses on lncRNAs that have been implicated in the pathogenesis of hematopoietic malignancies.

Keywords: ALL; AML; CML; MDS; MPN; lncRNA.

Publication types

Review

MeSH terms

Gene Expression Regulation, Neoplastic*
Hematologic Neoplasms / genetics*
Hematologic Neoplasms / pathology*
Humans
RNA, Long Noncoding / genetics*

Substances

RNA, Long Noncoding