Abstract
Using 3,5-bis(trifluoromethyl)benzene-modified bisbenzimide H33258, bulged-out nucleobases on a DNA strand can be detected by the chemical shift change in (19)F NMR. Based on this technique, single-nucleotide polymorphisms on a DNA sequence can be analyzed simultaneously.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Bisbenzimidazole / chemistry*
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DNA / chemistry*
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DNA / genetics*
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Feasibility Studies
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Fluorine / chemistry*
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Models, Molecular
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Nucleic Acid Conformation*
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Polymorphism, Single Nucleotide*
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Time Factors
Substances
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Fluorine
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DNA
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Bisbenzimidazole