Toward more predictive genetic mouse models of Alzheimer's disease

Abstract

Genetic mouse models for Alzheimer's disease (AD) have been widely used to understand aspects of the biology of the disease, but have had limited success in translating these findings to the clinic. In this review, we discuss the benefits and limitations of existing genetic models and recent advances in technologies (including high throughput sequencing and genome editing) that promise more predictive models. We summarize widely used biomarkers and behavioral tests for mouse models of AD and highlight best practices that will maximize translatability of preclinical findings.

Keywords: Alzheimer’s disease; Biomarkers; Genetic model; Genomics; Mouse model; Neuroinflammation; Preclinical model; Translational assays.