Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging

Chem Commun (Camb). 2016 Feb 18;52(14):3030-3. doi: 10.1039/c5cc09724j.

Abstract

A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in a murine model of prostate cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biocompatible Materials*
  • Carbon Isotopes / chemistry*
  • Carbon-13 Magnetic Resonance Spectroscopy
  • Hydrogen-Ion Concentration*

Substances

  • Biocompatible Materials
  • Carbon Isotopes