Pancreatic Intraepithelial Neoplasia

Toby C Cornish; Ralph H Hruban

doi:10.1016/j.path.2011.03.005

Pancreatic Intraepithelial Neoplasia

Surg Pathol Clin. 2011 Jun;4(2):523-35. doi: 10.1016/j.path.2011.03.005. Epub 2011 May 30.

Authors

Toby C Cornish¹, Ralph H Hruban²

Affiliations

¹ Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, The Johns Hopkins Hospital, Weinberg Building, Room 2242, 401 North Broadway, Baltimore, MD 21231, USA.
² Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, The Johns Hopkins Hospital, Weinberg Building, Room 2242, 401 North Broadway, Baltimore, MD 21231, USA. Electronic address: rhruban@jhmi.edu.

PMID: 26837486
DOI: 10.1016/j.path.2011.03.005

Abstract

Pancreatic intraepithelial neoplasias (PanINs) are microscopic lesions of the pancreas. Traditionally viewed as a benign metaplasia of small ducts, evidence suggests that PanINs are neoplastic and that some PanINs progress to invasive ductal adenocarcinoma. The primary diagnostic challenge is distinguishing PanINs from other lesions, including invasive ductal adenocarcinoma, intraductal papillary mucinous neoplasm, and cancerization of benign ducts. PanINs are the most common of the pancreatic cancer precursor lesions, yet they remain poorly understood and are so small that they are almost clinically undetectable. Further study is required to define the role of PanINs in the carcinogenesis and early detection of pancreatic cancer.

Keywords: Acinar ductal metaplasia; Carcinogenesis; Lobulocentric atrophy; PanIN; Pancreas; Pancreatic cancer precursors; Pancreatic ductal adenocarcinoma; Pancreatic intraepithelial neoplasia.

Publication types

Review