Zebrafish Reel in Phenotypic Suppressors of Autism

Neuron. 2016 Feb 17;89(4):673-5. doi: 10.1016/j.neuron.2016.02.005.

Abstract

Chemical genetics can help decipher novel pathways underlying neurodevelopmental psychiatric impairments. Hoffman et al. (2016) utilized behavioral profiling of psychoactive compounds in zebrafish and identified estrogens as suppressors of a phenotype resulting from loss of an autism risk gene.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autistic Disorder / drug therapy*
  • Estrogens / pharmacology*
  • Gene Expression Regulation / drug effects*
  • Gene Expression Regulation / genetics*
  • Humans
  • Membrane Proteins / genetics*
  • Mutation / genetics*
  • Nerve Tissue Proteins / genetics*

Substances

  • Estrogens
  • Membrane Proteins
  • Nerve Tissue Proteins