Getting a Grip on Microtubules

Julia Schaletzky; Michael Rape

doi:10.1016/j.cell.2016.02.016

Getting a Grip on Microtubules

Cell. 2016 Feb 25;164(5):836-7. doi: 10.1016/j.cell.2016.02.016.

Authors

Julia Schaletzky¹, Michael Rape²

Affiliations

¹ Cytokinetics, 280 East Grand Avenue, South San Francisco, CA 94080, USA.
² Howard Hughes Medical Institute, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: mrape@berkeley.edu.

PMID: 26919420
DOI: 10.1016/j.cell.2016.02.016

Abstract

Posttranslational modifications control microtubule behavior, yet assigning roles to particular signals was hampered by lack of defined in vitro systems. In this issue of Cell, Valenstein and Roll-Mecak establish a biochemical platform to interrogate consequences of microtubule polyglutamylation, thereby providing important insights into the specificity and quantitative nature of cellular information transfer.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adenosine Triphosphatases / metabolism*
Humans
Microtubules / metabolism*
Protein Processing, Post-Translational*
Spastic Paraplegia, Hereditary / metabolism*
Tubulin / metabolism*

Substances

Tubulin
Adenosine Triphosphatases

Grants and funding

Howard Hughes Medical Institute/United States