Proteostasis Maintenance of Cys-Loop Receptors

Yan-Lin Fu; Ya-Juan Wang; Ting-Wei Mu

doi:10.1016/bs.apcsb.2015.11.002

Proteostasis Maintenance of Cys-Loop Receptors

Adv Protein Chem Struct Biol. 2016:103:1-23. doi: 10.1016/bs.apcsb.2015.11.002. Epub 2015 Dec 22.

Authors

Yan-Lin Fu¹, Ya-Juan Wang², Ting-Wei Mu³

Affiliations

¹ Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
² Center for Proteomics and Bioinformatics and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
³ Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Electronic address: tingwei.mu@case.edu.

PMID: 26920686
DOI: 10.1016/bs.apcsb.2015.11.002

Abstract

The Cys-loop receptors play prominent roles in the nervous system. They include γ-aminobutyric acid type A receptors, nicotinic acetylcholine receptors, 5-hydroxytryptamine type-3 receptors, and glycine receptors. Proteostasis represents an optimal state of the cellular proteome in normal physiology. The proteostasis network regulates the folding, assembly, degradation, and trafficking of the Cys-loop receptors, ensuring their efficient functional cell surface expressions. Here, we summarize current advances about the protein biogenesis process of the Cys-loop receptors. Because operating on individual biogenesis steps influences the receptor cell surface level, manipulating the proteostasis network components can regulate the function of the receptors, representing an emerging therapeutic strategy for corresponding channelopathies.

Keywords: 5-HT(3)R; Assembly; Cys-loop receptors; ERAD; Endocytosis; Folding; GABA(A)R; Proteostasis; Trafficking; nAChR.

Publication types

Review

MeSH terms

Cell Membrane
Cysteine Loop Ligand-Gated Ion Channel Receptors / chemistry*
Cysteine Loop Ligand-Gated Ion Channel Receptors / metabolism
Endocytosis / genetics
Endoplasmic Reticulum / chemistry
Endoplasmic Reticulum / metabolism
Golgi Apparatus / chemistry
Golgi Apparatus / metabolism
Protein Folding
Protein Transport / genetics
Receptors, GABA / chemistry*
Receptors, GABA / metabolism
Receptors, Glycine / chemistry*
Receptors, Glycine / metabolism
Receptors, Nicotinic / chemistry*
Receptors, Nicotinic / metabolism
Receptors, Serotonin, 5-HT3 / chemistry*
Receptors, Serotonin, 5-HT3 / metabolism

Substances

Cysteine Loop Ligand-Gated Ion Channel Receptors
Receptors, GABA
Receptors, Glycine
Receptors, Nicotinic
Receptors, Serotonin, 5-HT3