FITT principle (frequency, intensity, time, and type) of exercise is a framework for exercise prescription. A general recommendation is to accumulate at least 30 minutes of moderate-intensity exercise on most days of the week (total of 150 minutes per week). In this article, evidence was reviewed to clarify optimum exercise conditions for managing lifestyle-related diseases such as hypertension, diabetes, dyslipidemia, obesity and metabolic syndrome. The effect of resistance exercise was also reviewed.