Meroterpenoid enantiomers from Ganoderma sinensis

Fitoterapia. 2016 Apr:110:110-5. doi: 10.1016/j.fitote.2016.03.003. Epub 2016 Mar 3.

Abstract

Zizhines A-F (1-6), six pairs of new meroterpenoid enantiomers and a known meroterpenoid (7) were isolated from the fruiting bodies of Ganoderma sinensis. The structures and absolute configurations of the new substances were assigned by spectroscopic and computational methods. All the compounds apart from 7 were evaluated for their inhibition on extracellular matrix component (fibronectin) generation by using TGF-β1-induced rat kidney tubular epithelial cells. Although none of them was found to be active in these cells, the present findings add new facets for the chemistry of Ganoderma.

Keywords: Extracellular matrix production; Fornicin A (PubChem CID:16086601); Ganoderma sinensis; Meroterpenoids; Zizhines A–F.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Epithelial Cells / drug effects*
  • Extracellular Matrix / metabolism
  • Fibronectins / metabolism
  • Ganoderma / chemistry*
  • Kidney Tubules / cytology
  • Molecular Structure
  • Rats
  • Stereoisomerism
  • Terpenes / chemistry*
  • Terpenes / isolation & purification
  • Transforming Growth Factor beta1 / pharmacology

Substances

  • Fibronectins
  • Terpenes
  • Transforming Growth Factor beta1