Sticking Around: Short-Range Activity of Wnt Ligands

Michael Boutros; Christof Niehrs

doi:10.1016/j.devcel.2016.02.018

Sticking Around: Short-Range Activity of Wnt Ligands

Dev Cell. 2016 Mar 7;36(5):485-6. doi: 10.1016/j.devcel.2016.02.018.

Authors

Michael Boutros¹, Christof Niehrs²

Affiliations

¹ Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ) and Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg University, 69120 Heidelberg, Germany. Electronic address: m.boutros@dkfz.de.
² Division of Molecular Embryology, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany; Institute of Molecular Biology (IMB), 55128 Mainz, Germany.

PMID: 26954543
DOI: 10.1016/j.devcel.2016.02.018

Abstract

Wnt ligands are secreted lipid-modified proteins that are essential for development and homeostasis. Published recently in Nature, Farin et al. (2016) report that Wnt3 acts at a short distance during growth of mouse intestinal organoids, suggesting that Wnt proteins remain membrane-bound to activate signaling at a short range from their source.

Publication types

Comment

MeSH terms

Animals
Cell Membrane / metabolism*
Female
Intestinal Mucosa / cytology*
Male
Stem Cell Niche*
Stem Cells / cytology*
Stem Cells / metabolism*
Wnt Signaling Pathway*
Wnt3 Protein / metabolism*

Substances

Wnt3 Protein