Capsular Typing Method for Streptococcus agalactiae Using Whole-Genome Sequence Data

J Clin Microbiol. 2016 May;54(5):1388-90. doi: 10.1128/JCM.03142-15. Epub 2016 Mar 9.

Abstract

Group B streptococcus (GBS) capsular serotypes are major determinants of virulence and affect potential vaccine coverage. Here we report a whole-genome-sequencing-based method for GBS serotype assignment. This method shows strong agreement (kappa of 0.92) with conventional methods and increased serotype assignment (100%) to all 10 capsular types.

Publication types

  • Evaluation Study

MeSH terms

  • Bacterial Capsules / genetics*
  • Genome, Bacterial
  • Humans
  • Molecular Typing / methods*
  • Sequence Analysis, DNA
  • Serotyping / methods
  • Streptococcus agalactiae / classification*
  • Streptococcus agalactiae / genetics*