Zika Virus: New Clinical Syndromes and Its Emergence in the Western Hemisphere

J Virol. 2016 Apr 29;90(10):4864-4875. doi: 10.1128/JVI.00252-16. Print 2016 May 15.

Abstract

Zika virus (ZIKV) had remained a relatively obscure flavivirus until a recent series of outbreaks accompanied by unexpectedly severe clinical complications brought this virus into the spotlight as causing an infection of global public health concern. In this review, we discuss the history and epidemiology of ZIKV infection, recent outbreaks in Oceania and the emergence of ZIKV in the Western Hemisphere, newly ascribed complications of ZIKV infection, including Guillain-Barré syndrome and microcephaly, potential interactions between ZIKV and dengue virus, and the prospects for the development of antiviral agents and vaccines.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aedes / virology
  • Animals
  • Dengue Virus / immunology
  • Dengue Virus / physiology
  • Disease Outbreaks
  • Disease Reservoirs / virology
  • Female
  • Global Health
  • Guillain-Barre Syndrome / etiology
  • Guillain-Barre Syndrome / virology
  • Humans
  • Infectious Disease Transmission, Vertical
  • Microcephaly / virology
  • Mosquito Vectors / virology
  • Oceania / epidemiology
  • Pregnancy
  • Pregnancy Complications, Infectious / virology
  • Viral Vaccines
  • Zika Virus / genetics
  • Zika Virus / physiology*
  • Zika Virus Infection / complications
  • Zika Virus Infection / epidemiology*
  • Zika Virus Infection / transmission
  • Zika Virus Infection / virology*

Substances

  • Viral Vaccines