Simultaneous determination of phenolic compounds in sesame oil using LC-MS/MS combined with magnetic carboxylated multi-walled carbon nanotubes

Abstract

A novel magnetic carboxylated multi-walled carbon nanotubes (c-MWCNT-MNPs) was proposed for magnetic solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry to determine phenolic compounds in sesame oil. In this study, c-MWCNT-MNPs were acquired by simply dispersing Fe3O4 magnetic nanoparticles into carboxylated multi-walled carbon nanotubes. The major parameters affecting extraction efficiency were optimized, including the type and volume of desorption solvents, extraction and desorption time, washing solution, and sorbent amount. The limit of quantifications and limit of detections were from 0.03μg/kg to 43.00μg/kg and from 0.01μg/kg to 13.60μg/kg, respectively. The recoveries of phenolic compounds in vegetable oils were in the range of 83.8-125.9% with inter-day and intra-day precisions of less than 13.2%. It was confirmed that this method was simple, rapid and reliable with an excellent potential for routine analysis of phenolic compounds in oil samples.

Keywords: 2-(4-Hydroxyphenyl) ethanol (Pubchem CID: 10393); 2-Hydroxycinnamic acid (Pubchem CID: 637540); 3,4-Dihydroxybenzoic acid (Pubchem CID: 72); Apigenin (Pubchem CID: 5280443); Caffeic acid (Pubchem CID: 689043); Catechin (Pubchem CID: 73160); Cinnamic acid (Pubchem CID: 444539); Daidzein (Pubchem CID: 5281708); Daidzin (Pubchem CID: 107971); Epicatechin (Pubchem CID: 72276); Ferulic acid (Pubchem CID: 445858); Gallic acid (Pubchem CID: 370); Genistein (Pubchem CID: 5280961); Genistin (Pubchem CID: 5281377); Liquid chromatography–tandem mass spectrometry; Luteolin (Pubchem CID: 5280445); Magnetic carboxylated multi-walled carbon nanotubes; Phenolic compounds; Quercetin (Pubchem CID: 5280343); Sesame oil; Sesamin (Pubchem CID: 44714838); Sinapic acid (PubChem CID: 637775); Sinapic alcohol (Pubchem CID: 5280507); Syringic acid (Pubchem CID: 10742); Vanillic acid (Pubchem CID: 8468); p-Coumaric acid (Pubchem CID: 637542); trans-Resveratrol (Pubchem CID: 445154).