Current trends in oxysterol research

Biochem Soc Trans. 2016 Apr 15;44(2):652-8. doi: 10.1042/BST20150255.

Abstract

In this short review we provide a synopsis of recent developments in oxysterol research highlighting topics of current interest to the community. These include the involvement of oxysterols in neuronal development and survival, their participation in the immune system, particularly with respect to bacterial and viral infection and to Th17-cell development, and the role of oxysterols in breast cancer. We also discuss the value of oxysterol analysis in the diagnosis of disease.

Keywords: RAR-related orphan receptor gamma t (RORγ); cholestenoic acid; cholesterol; hydroxycholesterol; liver X receptor (LXR); sterol regulatory-element binding protein (SREBP).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Survival
  • Cholestanols / metabolism
  • Humans
  • Imidazoles / metabolism
  • Immune System / metabolism
  • Neurons / cytology
  • Oxysterols / metabolism*
  • Receptors, Estrogen / metabolism

Substances

  • 5-hydroxy-6-(2-(1H-imidazol-4-yl)ethylamino)cholestan-3-ol
  • Cholestanols
  • Imidazoles
  • Oxysterols
  • Receptors, Estrogen