NORAD: Defender of the Genome

Trends Genet. 2016 Jul;32(7):390-392. doi: 10.1016/j.tig.2016.04.002. Epub 2016 May 5.

Abstract

Long non-coding RNAs (lncRNAs) are a fascinating, but still largely uncharacterized, class of genes. A recent paper by the Mendell group identifies NORAD, a novel lncRNA that is regulated in response to DNA damage and plays a key role in maintaining genome integrity by modulating the activity the RNA binding proteins PUM2 and PUM1.

Keywords: CIN; NORAD; PUM1; PUM2; genomic stability; lncRNA.

Publication types

  • Review
  • Comment

MeSH terms

  • Amino Acid Sequence / genetics
  • Animals
  • DNA Damage / genetics*
  • Genome
  • Humans
  • Mammals / genetics
  • RNA, Long Noncoding / genetics*
  • RNA-Binding Proteins / genetics*

Substances

  • NORAD long non-coding RNA, human
  • PUM1 protein, human
  • PUM2 protein, human
  • RNA, Long Noncoding
  • RNA-Binding Proteins